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Updated: Jul 16, 2025

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
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由基于PEG的制药辅助剂诱导的PEG化纳米颗粒的加速血液清除

Guifeng Miao1, Yuejian He1, Keren Lai1

  • 1Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, 510515 Guangzhou, Guangdong Province, China.

Journal of controlled release : official journal of the Controlled Release Society
|September 17, 2023
PubMed
概括

通常使用的基于PEG的辅助剂,如Poloxamer188,可以诱导抗PEG抗体,导致PEG化纳米药物的血液清理加速 (ABC),并降低癌症治疗的有效性. 波洛克萨默407的冲击是最小的.

关键词:
这就是ABC效应.对抗PEG抗体的抗体.经PEG化纳米粒子.制药辅助剂 制药辅助剂 制药辅助剂聚乙烯甘醇 (PEG) 是一种聚乙烯甘醇.

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