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用于持续释放药物输送系统的工程治疗蛋白质

Thoa Thi Kim Nguyen¹, Khang-Yen Pham¹, Simmyung Yook²

¹College of Pharmacy, Keimyung University, 1095 Dalgubeol-daero, Dalseo-Gu, Daegu 42601, Republic of Korea.

Acta biomaterialia

|September 17, 2023

概括

蛋白质疗法提供有针对性的治疗,但面临着短半衰期等挑战. 结构修改和先进的传递系统是提高它们的稳定性和治疗疾病的有效性的关键.

科学领域:

生物技术和制药科学生物技术和制药科学
药物输送系统药物输送系统
蛋白质工程是指蛋白质工程.

背景情况:

蛋白质疗法对于治疗癌症和炎症等疾病至关重要,因为它们的特异性和低毒性.
临床使用受到短半衰期,免疫性和透性差的限制,从而降低了药物的整体有效性.
结构修改和控制释放系统对于克服这些局限性至关重要.

研究的目的:

审查最近在蛋白质疗法的结构修改方面的进展.
探索持续蛋白质药物释放的最先进的长期输送系统.
确定未来研究领域,以最大限度地发挥蛋白质疗法的潜力.

主要方法:

对结构修饰策略的审查:PEGylation,糖化,多氨基酸修饰和基因工程.
对各种可控释放输送系统的分析:基于聚合物 (凝,植入物,微/纳米粒子),基于脂质 (脂质体,SLN,NLC) 和无机纳米粒子.
综合当前关于增强蛋白质稳定性和功能性的研究.

主要成果:

结构修改可以增加分子大小,延长稳定性和血半衰期.
先进的输送系统,包括聚合物,脂质和无机纳米颗粒,显示了持续和向蛋白质释放的前景.
在蛋白质修饰和输送系统开发方面都取得了重大进展.

结论:

优化蛋白质疗法需要结构修改和复杂的输送系统的双重方法.
需要进一步的研究才能充分实现蛋白质药物对人类健康的治疗潜力.
控制释放系统对于保持蛋白质稳定性和确保治疗疗效至关重要.

关键词:

长期交付系统长期交付系统纳米颗粒纳米颗粒蛋白质治疗药物蛋白质治疗药物结构修改是指结构的修改.持续释放的释放是一种持续释放.

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