Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Microneedle technologies in emerging strategies for non-transdermal drug delivery.

International journal of pharmaceutics·2026
Same author

Optimizing intravenous solid tumour treatment through active targeting approaches and polymeric micelles engineering: A meta-analysis in mouse models.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Nanorobotics at a crossroads: an overview of design, propulsion, and applications.

International journal of pharmaceutics·2026
Same author

Integrating artificial intelligence into drug delivery systems: Formulation development and current challenges.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same author

Targeting the brain: alternative administration routes and drug delivery systems for antidepressant therapy.

Expert opinion on drug delivery·2026
Same author

Plant-Based Nano-Delivery Systems in the Treatment of Inflammatory Disorders.

Pharmaceutics·2026

相关实验视频

Updated: Jul 16, 2025

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

4.6K

一个通过设计的质量框架,用于开发纳米晶体生物启用配方.

Ana Simões1, Ricardo A E Castro2, Francisco Veiga1

  • 1Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; Associated Laboratory for Green Chemistry of the Network of Chemistry and Technology (LAQV/REQUIMTE), Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.

International journal of pharmaceutics
|September 17, 2023
PubMed
概括
此摘要是机器生成的。

这项研究使用高压均质化和设计质量开发了稳定的皮纳米晶配方. 优化的配方显示了皮肤透和药物释放的增强,为药物输送提供了有前途的"绿色"方法.

关键词:
中心复合设计设计结晶性是指结晶性是指结晶性.纳米晶体是一种纳米晶体.业绩表现 业绩表现 业绩表现表现物理稳定性 物理稳定性从设计开始的质量.固态硬件是一种固态硬件.局部皮肤病产品 局部皮肤病产品

更多相关视频

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.2K
Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

7.9K

相关实验视频

Last Updated: Jul 16, 2025

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

4.6K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.2K
Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

7.9K

科学领域:

  • 制药纳米技术 制药纳米技术
  • 药物输送系统 药物输送系统

背景情况:

  • 开发稳定和有效的局部配方药物,如皮是改善治疗结果至关重要的.
  • 纳米晶技术为提高药物的溶解性,生物可用性和皮肤透性提供了一个有希望的途径.

研究的目的:

  • 使用可扩展的高压均质化 (HPH) 技术设计和优化1.0%的皮纳米晶配方.
  • 采用设计质量 (QbD) 方法,以确保强大且可重复的制造工艺.
  • 为了改善皮肤透性和稳定性,用皮的配方.

主要方法:

  • 利用高压同质化 (HPH) 进行皮的纳米化.
  • 采用设计质量 (QbD) 方法,包括故障模式,效应和关键性分析 (FMECA) 和中央复合设计 (CCD).
  • 研究了烯度,soluplus度和HPH时间对关键质量属性 (CQA) 的影响.

主要成果:

  • 获得了具有最佳颗粒大小 (311.8 nm) 和狭窄分布的皮纳米晶体.
  • 与传统形式相比,体外药物释放率有所提高,皮肤穿透流量有所改善.
  • 为关键过程参数定义了一个强大的设计空间 (DS),确保配方稳定性和性能.

结论:

  • 开发的皮纳米晶配方,通过无有机溶剂的HPH方法生产,表现出优越的物理化学特性和增强的治疗潜力.
  • QbD方法成功地确定了关键变量,并为稳定有效的药物产品建立了最佳的制造条件.
  • 这种"绿色"纳米晶体技术为制药研究和开发带来了重大进步,可以创建改进的药物输送系统.