青少年暴露于酒精会通过改变中枢杏仁体电路功能的变化产生特定性别的长期过敏症
Maria E Secci1, Leslie K Kelley1, Elizabeth M Avegno2
1Department of Physiology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana.
Biological psychiatry
|September 17, 2023
概括
青少年接触酒精会通过改变大脑电路,导致雄性大鼠长期疼痛敏感. 激活特定的大脑路径可以逆转这些酒精引起的疼痛变化.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 青少年心理学 青少年心理学
背景情况:
- 青少年暴露在酒精中对成年人有持久的影响.
- 虽然急性酒精可以缓解疼痛,但长期使用会增加疼痛敏感度.
- 了解这些长期影响对于公众健康至关重要.
研究的目的:
- 调查青少年间歇性乙醇 (AIE) 暴露对男性和女性大鼠疼痛行为和大脑功能的长期影响.
- 为了检查AIE对中枢桃体 (CeA) - - 腹侧侧水管灰色 (vlPAG) 途径中的突触传输的影响.
- 确定CeA-vlPAG电路在调解AIE诱导的疼痛过敏症中的作用.
主要方法:
- 在青少年大鼠中慢性间歇性乙醇暴露.
- 与疼痛相关的行为测试.
- 在投射到vlPAG的CeA神经元中的全细胞电生理学.
- 使用专门由设计药物 (DREADDs) 激活的设计受体进行电路操纵.
主要成果:
- 在雄性大鼠中,AIE诱导了长期的超痛症 (增加疼痛敏感性),但不是雌性大鼠.
- 在AIE之后,雄性大鼠的CeA神经元向vlPAG投射的突触强度降低了.
- CeA-vlPAG电路的激活缓解了成年雄性大鼠的AIE诱导的过敏症.
结论:
- 青少年的酒精暴露导致疼痛处理和相关的神经回路的性别依赖的长期变化.
- 这些发现凸显了早期饮酒对成年人疼痛感知的重大影响.
- 这项研究确定了CeA-vlPAG通路作为缓解青少年饮酒长期疼痛后果的潜在治疗标.
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