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用免疫检查点抑制剂治疗肌肉侵入性膀癌的膀节约治疗

Chao Xu¹, Wen Zou¹, Yinhuai Wang²

¹Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China.

Critical reviews in oncology/hematology

|September 17, 2023

概括

免疫检查点抑制剂为肌肉侵入性膀癌 (MIBC) 提供膀保护选择. 虽然有希望,但预测PD-L1等生物标志物的治疗成功仍然存在争议,需要进一步的试验.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

肌肉侵入性膀癌 (MIBC) 管理通常涉及激进囊切除术.
膀保护疗法 (BPT) 是选择MIBC患者的替代方案.
免疫检查点抑制剂 (ICI) 在BPT策略中越来越多地被探索.

研究的目的:

审查基于ICI的MIBC多式膀保护疗法.
评估不同ICI组合的疗效和安全性.
讨论生物标志物在预测治疗反应中的作用.

主要方法:

对MIBC基于ICI的BPT现有文献的审查.
对三种常见的ICI组合策略的分析:与化学放射治疗,单独辐射或化疗.
对安全概况和疗效数据的评估.

主要成果:

在MIBC BPT中,ICI组合显示出有希望的疗效和可管理的安全性.
常见的ICI策略包括与化学放射治疗,辐射或化疗的结合.
关于PD-L1表达的预测价值,瘤突变负担和基因变异的争论仍在继续.

结论:

使用ICI的多模式BPT是MIBC的囊切除术的可行替代方案.
需要进一步的大规模随机试验来优化基于ICI的BPT.
澄清生物标志物的作用对于个性化治疗选择至关重要.

关键词:

膀节约治疗膀节约治疗化学辐射疗法 (CRT) 是一种疗法.免疫检查点抑制剂 (ICI)膀的肌肉侵入性泌尿器癌 (MIBC) 是一种肌肉侵袭性癌症.三种方式治疗 (TMT)

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