骨关节炎集群随机试验中的集群内相关系数:系统性审查
Lauren K King1, Nicolas S Bodmer2, Pakeezah Saadat3
1Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada; Li Ka Shing Research Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Osteoarthritis and cartilage
|September 17, 2023
概括
在骨关节炎集群随机试验中报告集群内相关系数 (ICC) 对于准确的样本大小和功率计算至关重要. 然而,很少有试验报告观察到ICC,这可能导致研究不足.
科学领域:
- 临床试验方法论 临床试验方法论
- 生物统计学 生物统计学
- 风湿病学研究 风湿病学研究
背景情况:
- 集群随机试验 (CRT) 需要考虑集群内相关性.
- 集群内相关系数 (ICC) 对于CRT的样本大小和功率计算至关重要.
- 综合报告试验标准 (CONSORT) 建议报告观察到的ICC.
结论:
- 尽管有CONSORT的建议,但在OA集群RCT中报告观察到的ICC存在重大差距.
- 这种报告不足妨碍了对试验结果的准确解释和未来研究设计.
- 解决这一报告缺口对于提高OA CRT的质量和可靠性至关重要.
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