与雌激素相关的受体激动症逆转了老化脏中的线粒体功能障碍和炎症
Xiaoxin X Wang1, Komuraiah Myakala1, Andrew E Libby1
1Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, District of Columbia.
The American journal of pathology
|September 17, 2023
概括
与雌激素相关的受体 (ERR) 是与年龄相关的功能障碍的关键调节者. 激活ERR模仿卡路里限制,逆转脏衰老标志物和小鼠的炎症.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 线粒体生物学 线粒体生物学
背景情况:
- 功能随着年龄的增长而下降,由代谢综合征和高血压加剧.
- 线粒体功能障碍和炎症是年龄相关病的标志.
- 核激素受体,雌激素相关受体 (ERRs) 参与了这些过程.
研究的目的:
- 研究ERRs在与年龄相关的线粒体功能障碍和炎症中的作用.
- 为了确定ERR激活是否可以改善与年龄相关的衰退.
- 探索针对ERR或STING脏衰老途径的治疗潜力.
主要方法:
- 在老化的人类和老鼠脏中评估ERR表达,有和没有卡路里限制 (CR).
- 用泛ERR激动剂 (SLU-PP-332) 或STING抑制剂 (C-176) 治疗老年小鼠.
- 在治疗后评估功能,细胞健康,线粒体功能和炎症标志物.
主要成果:
- 在衰老的脏中,ERRs降低了,但在CR中保留了.
- 泛ERRagonist治疗逆转了与年龄相关的白蛋白尿,细胞损失,线粒体功能障碍和炎症.
- 用STING抑制剂治疗减少了炎症和衰老标志物,并意外地恢复了线粒体组件和ERR表达.
结论:
- ERRs作为CR模仿剂,是与年龄相关的线粒体功能障碍和炎症的关键调节器.
- 准ERR或STING通路为预防与年龄相关的病进展提供了新的治疗策略.
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