类固醇激素受体N端域的结构和功能
1Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY, United States.
Vitamins and hormones
|September 17, 2023
概括
类固醇激素受体 (SHRs) 调节基因表达. 了解内在无序的N端域 (NTD) 是改善内分泌相关癌症治疗的关键.
科学领域:
- 分子生物学分子生物学
- 内分泌学 在内分泌学.
- 结构生物学 结构生物学
背景情况:
- 类固醇激素受体 (SHRs) 是关键的核受体,在生理和病理过程中调节基因表达.
- 基于SHR的疗法对于内分泌疾病至关重要,但在治疗内分泌相关癌症方面面临挑战.
- 需要更深入地了解SHR结构动态,特别是N终端域 (NTD),以克服治疗的局限性.
研究的目的:
- 审查有关SHR行动的当前知识,重点关注NTD的结构和功能.
- 突出NTD结构动态在SHR全调节和基因表达中的重要性.
- 提供有关NTD灵活性如何影响SHR细胞/组织特异性功能的见解.
主要方法:
- 关于SHR结构生物学和信号机制的最新进展的文献综述.
- 对研究的分析,该研究将SHR结构信息与动态细胞环境中的受体作用相关联.
- 综合目前关于NTD在全调节和基因表达微调中的作用的理解.
主要成果:
- SHR NTD 本质上是无序的,表现出对功能至关重要的结构灵活性.
- NTD的结构动力学有助于SHRs的全调节.
- 这种灵活性允许微调目标基因表达,控制SHR细胞/组织特异性功能.
结论:
- 结构生物学的进步为SHR机制和NTD的作用提供了新的见解.
- 准NTD结构动态为改善内分泌相关疾病的治疗策略提供了潜力.
- 对SHR NTD结构功能关系的进一步研究对于临床应用至关重要.
相关概念视频
01:08Intracellular Hormone Receptors
55.5K
Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
55.5K
01:31Internal Receptors
70.3K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
70.3K
01:31Transducer Mechanism: Nuclear Receptors
1.4K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.4K
01:07Types of Receptors: Internal Receptors
25.5K
Many cellular signals are hydrophilic and cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind intracellular receptors that reside within the cell cytoplasm or nucleus. Many mammalian steroid hormones and nitric oxide (NO) gas use this cell signaling mechanism.
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
25.5K
01:45Endocrine Signaling
64.4K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
64.4K
01:30Assembly of Signaling Complexes
5.8K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.8K