人类的葡萄糖皮质体受体
Nicolas C Nicolaides1, George P Chrousos1
1Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, Athens, Greece; Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; University Research Institute of Maternal and Child Health and Precision Medicine and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens Medical School, Athens, Greece.
葡萄糖皮质激素,由下丘脑-垂体-上腺 (HPA) 轴和昼夜节律调节,是关键的类固醇激素. 本综述详细介绍了人类葡萄糖皮质体受体 (GR),其结构,功能和健康和疾病中的信号.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 葡萄糖皮质激素是上腺皮质产生的类固醇激素.
- 它们是生理功能的关键调节者,由下丘脑-垂体-上腺 (HPA) 轴和昼夜节律控制.
- 葡萄糖皮质体通过与葡萄糖皮质体受体 (GR) 结合来发挥其作用.
研究的目的:
- 总结关于人类葡萄糖皮质体受体 (GR) 的当前知识.
- 为GR结构,表达,功能和信号提供洞察力.
- 讨论GR在正常生理和病理条件中的作用.
主要方法:
- 审查当前的科学文献.
- 结合了来自细胞,分子和计算结构生物学的发现.
- 考虑表观遗传机制.
主要成果:
- 葡萄糖皮质体受体 (GR) 是一个无处不在的转录因子,影响着高达20%的哺乳动物基因组.
- 对GR的分子机制的理解有了显著的进步.
- 人们越来越认识到GR在各种生理和病理状态中的参与.
结论:
- 人类的葡萄糖皮质体受体 (GR) 在调节基因转录和生理过程中发挥着核心作用.
- 生物学和表观遗传学的进步提高了我们对GR信号的理解.
- 这种知识对于理解和管理与葡萄糖皮质体功能相关的疾病至关重要.
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