白噪声 - - 晚年生活中的焦虑是否与白物质超强度负担有关?
Andrew R Gerlach1, Helmet T Karim2, Soyoung Lee3
1Department of Psychiatry (ARG, HTK, DLT, MAB, CA), University of Pittsburgh, Pittsburgh, PA.
概括
焦虑,特别是担心,与老年人白质过强度 (WMH) 有关. 执行功能 (EF) 可能在这种关系中发挥作用,特别是在晚年或有显著WMH时.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 老年学是一门学科.
背景情况:
- 焦虑现象,包括全球焦虑,担忧和反,在老年人中很普遍.
- 白质超强度 (WMH) 是衰老中常见的神经成像发现,与认知衰退有关.
- 老年人的焦虑,WMH和执行功能 (EF) 之间的相互作用需要进一步调查.
研究的目的:
- 研究老年人不同焦虑现象 (全球焦虑,担忧,反) 和白质过强度 (WMH) 之间的关系.
- 调查执行功能 (EF) 在焦虑表型和WMH之间的关联中所起的调节作用.
- 探索年龄对这些关系的影响.
主要方法:
- 一项涉及110名来自社区的老年人 (年龄≥50岁) 的横截面研究.
- 评估人口统计,累积的疾病负担,焦虑表型 (全球焦虑,担忧,反) 和执行功能 (EF).
- 使用磁共振成像对白质超强度 (WMH) 的量化.
主要成果:
- 较低的全球焦虑和焦虑严重程度与较高的WMH体积相关,尽管全球焦虑相关性随着年龄调整而减弱.
- 化与WMH负担没有显著的关联.
- 执行功能 (EF) 与焦虑表型或WMH没有直接相关,但焦虑和EF,以及EF和WMH之间的关联,出现在年龄较大和/或WMH负担较大的个体中.
结论:
- 焦虑,特别是担心,与老年人白质过强度 (WMH) 有关.
- 执行功能 (EF) 可能起到复杂的作用,在特定子组 (高级年龄,高WMH负担) 中可能与担忧和WMH相互作用.
- 需要进行长期研究,以阐明焦虑,WMH和EF之间的复杂动态.
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