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适合儿童的咳药 - - 现在是实践检查的时候了
Gene Clark1, Dominic A Fitzgerald2, Bruce K Rubin3
1Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Paediatric respiratory reviews
|September 17, 2023
概括
儿童非处方咳药缺乏经过证明的有效性,并可能造成伤害. 由于安全问题和延迟诊断的可能性,应避免使用这些药物,特别是在幼儿中.
科学领域:
- 儿科药理学 儿科药理学
- 呼吸系统药物 呼吸系统药物
- 基于证据的医学是基于证据的医学.
背景情况:
- 一个多世纪以来,咳药物已被广泛用于治疗儿童咳症状.
- 这些非处方药 (OTC) 含有各种成分,如阿片类药物,抗胰岛素药物,粘菌剂和液剂.
- 尽管它们很受欢迎,但在过去二十年中,人们对有效性和安全性的担忧越来越大.
研究的目的:
- 审查咳的保护性生理作用.
- 分析干咳与湿咳之间相互矛盾的治疗目标.
- 评估与特定治疗方法相比,OTC咳药物的证据,并讨论监管行动.
主要方法:
- 对儿科咳药物的证据基础的文献综述.
- 与喘和感染等疾病的向疗法进行OTC咳治疗的比较.
- 对监管干预和临床医生对OTC咳药物使用的担忧的分析.
主要成果:
- 儿童的OTC咳药物已经证明缺乏有效性.
- 这些药物可以延迟诊断更严重的潜在疾病.
- 包括严重并发症和死亡在内的不良事件与它们的使用有关.
结论:
- 在儿童中使用OTC咳药物没有证据支持,并带有重大风险.
- 冲突的治疗目标 (抑制与吐) 复杂化了它们的使用.
- 建议不要在儿童,特别是年幼儿童中使用OTC咳药物.
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