肝硬化患者的紧急尾切除术后的结果:来自英格兰的基于人口的队列研究
Alfred Adiamah1, Adil Rashid2, Colin J Crooks2
1National Institute for Health Research Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust, E Floor West Block, QMC Campus, Nottingham, NG7 2UH, UK. Alfie.adiamah@nottingham.ac.uk.
Langenbeck's archives of surgery
|September 17, 2023
概括
肝硬化患者在紧急尾切除术后90天内死亡的风险增加了三倍. 这突显了肝患者尾切除术的死亡风险增加.
科学领域:
- 外科手术 医疗外科手术
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 肝硬化患者的尾切除术带有预测较高的死亡风险,由于出血,感染和肝脏不补偿.
- 这项研究解决了在这个特定的患者群体中量化90天死亡风险的需要.
研究的目的:
- 确定诊断为肝硬化患者的紧急尾切除术后的90天死亡风险.
- 为了比较患有肝硬化和没有肝硬化,接受紧急尾切除术的患者之间的结果.
主要方法:
- 一项以人口为基础的队列研究利用了英格兰 (2001-2018) 的链接电子医疗数据库.
- 确定了接受紧急尾切除术的成年患者,并提取了肝硬化状态,并发病情况和结果的数据.
- 使用后勤回归来计算90天死亡率的几率比率,并根据人口和临床因素进行调整.
主要成果:
- 该研究包括40,353名患者,其中75名 (0.19%) 患有肝硬化. 肝硬化患者年龄较大,并患有更多的并发症.
- 肝硬化患者的90天病例死亡率明显高 (6.67%) 与没有肝硬化患者 (0.56%) 相比.
- 肝硬化患者的住院时间更长,再入院率更高,90天死亡率的调整后几率比率为3.75.
结论:
- 肝硬化患者在紧急尾切除术后90天死亡的几率增加了三倍.
- 这些发现强调了在肝硬化患者中尾切除术相关的风险增加.
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