在严重的COVID-19患者中,细胞外矩阵重塑的循环标记
Sarah Louise Murphy1,2, Bente Halvorsen1,2,3, Jan Cato Holter2,4
1Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
严重的COVID-19涉及到细胞外矩阵 (ECM) 的重塑. 关键调解剂如骨质松丁 (OPN),S100A12和YKL-40与疾病严重程度和死亡率有关.
科学领域:
- 生物医学研究的研究.
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
背景情况:
- 异常的细胞外基质 (ECM) 重塑与肺炎和纤维化有关.
- ECM重塑可能有助于严重COVID-19的病原体.
- 调查COVID-19中的ECM重塑调解器对于了解疾病进展至关重要.
研究的目的:
- 检查COVID-19患者中ECM重塑媒介的循环水平.
- 为了将这些介质水平与疾病严重程度,死亡率和肺病理学相关联.
- 为了探索SARS-CoV-2对ECM介质释放的直接影响.
主要方法:
- 分析了414名住院COVID-19患者的连续血液样本.
- 酶免疫测试在住院期间和3个月的随访期间量化了ECM重塑介质.
- 在体外实验中评估了非活化的SARS-CoV-2对细胞系中ECM介质释放的影响.
主要成果:
- 骨质疏松素 (OPN),S100A12和YKL-40水平与疾病严重程度和死亡率相关.
- 住院期间ECM介质水平升高预测了3个月后的肺病理.
- 暴露于SARS-CoV-2刺激了某些ECM介质从巨细胞和肺细胞中的释放.
结论:
- 在严重的COVID-19中,ECM重塑的变化很明显.
- OPN,S100A12和YKL-40可能在严重的COVID-19病变发生过程中发挥重要作用.
- 在SARS-CoV-2和特定ECM介质的释放之间存在直接联系.
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