纵向孤独,DNA甲基化年龄加速和认知功能之间的关联
Morgan Lynch1, Thalida Em Arpawong2, Christopher R Beam1,2
1Department of Psychology, University of Southern California, Los Angeles, California, USA.
概括
孤独会对老年人的认知功能和记忆产生负面影响. DNA甲基化 (DNAm) 衰老加速,特别是GrimAge Accel,部分解释了这种联系,突出了它在衰老生物标志物的作用.
科学领域:
- 老年学是一门学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 认知神经科学 认知神经科学
背景情况:
- 在老年人中,孤独是越来越令人担忧的问题.
- 孤独可能会通过生物学途径影响认知衰老.
- DNA甲基化 (DNAm) 加速衰老是衰老过程的一个潜在生物标志物.
研究的目的:
- 调查DNA甲基化 (DNAm) 加速年龄是否介导老年人孤独感和认知功能之间的关系.
- 检查基线孤独和纵向孤独轨迹对认知结果的影响.
- 确定与孤独和认知衰退相关的特定DNAm年龄加速措施.
主要方法:
- 利用了"健康与退休研究"中1814名老年人的数据.
- 评估了基线孤独和五个纵向孤独轨迹.
- 测量了六种常见的DNAm年龄加速措施和认知能力 (一般认知能力,即时/延迟记忆回忆,处理速度).
主要成果:
- 较高的基线孤独和最高的孤独轨迹与较差的认知能力和记忆有关.
- DNAm与并发病,生活方式和死亡风险相关的年龄加速措施调解了孤独对认知的影响,但不是处理速度.
- 在特定的孤独轨迹组中,GrimAge Accel调解了记忆结果.
结论:
- DNAm的衰老生物标志物,特别是GrimAge Accel,显示出解释孤独与认知功能之间的关联的潜力.
- 诸如自我评估健康,抑郁,社会隔离和BMI等共变量显著影响了孤独对认知的总和中介影响.
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