在临床大数据中探索患者药物坚持和数据挖掘方法:当代审查
Yixian Xu1, Xinkai Zheng2, Yuanjie Li3
1Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Journal of evidence-based medicine
|September 18, 2023
概括
机器学习和电子健康记录 (EHR) 和索赔数据库的数据挖掘改善了患者的药物服药. 分析这些大数据可以提高临床决策和患者护理质量.
科学领域:
- 医疗信息学 医疗信息学
- 数据科学数据科学数据科学
- 机器学习 机器学习
背景情况:
- 患者药物坚持数据越来越多地从索赔数据库和电子健康记录 (EHR) 中整合起来.
- 数据挖掘,特别是机器学习 (ML),对于从这些数据中提取可操作的见解至关重要.
- 不遵守会增加健康风险和医疗费用.
研究的目的:
- 审查ML技术在分析EHR数据中对药物坚持的应用.
- 探索医疗数据库的结构,相关的药物坚持.
- 利用监督和无监督的ML范式来研究遵守及其后果.
主要方法:
- 综合文献综述使用ML对药物坚持中的EHR应用.
- 对医疗数据库结构进行分析,以获取依从性数据.
- 监督和无监督ML技术的应用,以遵守数据.
主要成果:
- 医疗数据库 (例如,SEER,NHANES) 和ML对于临床大数据中的药物坚持分析是有效的.
- ML有助于挖掘患者的药物记录,以获得坚持的见解.
- 这些发现支持临床决策,风险分层和研究.
结论:
- 先进的数据挖掘和ML已经改变了药物坚持性研究,改善了患者的护理.
- 个性化干预和研究是推进治疗方法的关键.
更多相关视频
09:42Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
Published on: November 8, 2013
13.6K
11:21Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
Published on: July 27, 2018
8.2K
相关概念视频
01:12Analysis of Population Pharmacokinetic Data
291
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
291
01:28Drug Therapy
68
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
68
01:14Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches
174
Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
174
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:29Issues And Trends In Healthcare Delivery System
5.7K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.7K
00:59Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
94
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
94