时钟绘图测试:早期认知查中的错误类型和准确性
Karolina Sejunaite1, Frederic Gaucher1, Claudia Lanza1
1Department of Psychiatry and Psychfapy II Mental Health & Old Age Psychiatry, Ulm University, Ulm, Germany.
Journal of Alzheimer's disease : JAD
|September 18, 2023
概括
时钟绘图测试 (CDT) 显示对非常轻微的认知缺陷的使用有限,特别是在早期阿尔茨海默病 (AD) 和抑郁症 (DD) 查中. 分类分数比舒尔曼分数对轻度障碍提供了比舒尔曼分数更好的歧视.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 认知科学 认知科学
背景情况:
- 时钟绘图测试 (CDT) 是一种广泛使用的认知障碍查工具.
- 它的易用性与轻度认知障碍病例的预测价值差异化.
研究的目的:
- 评估用于查早期认知障碍的时钟绘图测试 (CDT).
- 专注于生物标志物验证的阿尔茨海默病 (AD) 和抑郁症 (DD).
主要方法:
- 分析了172名AD患者,70名DD患者和58名健康成年人的CDT表现.
- CDT评分使用了半定量 (舒尔曼) 和细分 (门德斯) 标准.
- 逻辑回归分析了基于迷你心理状态考试 (MMSE) 成绩的预测变量.
主要成果:
- 不均的数字间距是DD和AD患者具有高MMSE得分的重要预测因素.
- 随着MMSE分数的下降 (24-26),设置时钟针的错误变得具有预测性.
- 在低MMSE条件下 (AUC从0.739到0.827) CDT显示了AD和DD的可接受歧视.
- 在高MMSE条件下,分类得分显示了可接受的歧视,而舒尔曼得分对AD和DD的表现不佳.
结论:
- 对于查非常轻微的认知缺陷,特别是当认知表现仅略低于健康范围时,CDT的实用性有限.
- 理想情况下,现代诊断应该在显著的认知衰退之前进行有效的干预.
- 与舒尔曼评分相比,分类CDT评分可能在早期认知障碍中提供更好的歧视.
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