在拉丁裔成年人中背景和大脑健康中的融合:一个扩散电张器成像研究
Debra A Fleischman1,2,3, Konstantinos Arfanakis1,4,5, Shengwei Zhang1
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Journal of Alzheimer's disease : JAD
|September 18, 2023
概括
歧视和孤立等社会环境因素与老年拉丁裔的白质完整性降低有关. 这一大脑健康发现可能会增加轻度认知障碍 (MCI) 和阿尔茨海默病的风险.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 与非拉丁裔白人相比,拉丁裔人患轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 的风险更高.
- 同文化对这种风险的影响还未得到充分研究,特别是在影响老年拉丁裔大脑健康的社会环境和家庭因素方面.
研究的目的:
- 为了研究在拉丁裔老年人中背景文化与大脑健康之间的关系.
- 探索与归纳文化相关的社会环境和家庭因素如何影响白质完整性.
主要方法:
- 通过扩散张力成像 (DTI) 检查了三种文化化背景复合物 (文化化相关,社会环境,家庭主义) 与大脑白质完整性之间的关联.
- 分析了92名没有痴呆症的老拉丁裔成年人的数据,调整了人口统计和临床变量.
- 采用线性回归模型来评估积分复合物和DTI衍生的指标 (分数异构,FA) 之间的关系.
主要成果:
- 社会环境复合的较高分数与白质完整性降低有关,特别是较低的FA.
- 在两个左半球连接集群中观察到FA的减少,涉及额头,头顶和部区域.
结论:
- 老年拉丁裔人脑白质完整性降低与环境相关的社会环境经验有关.
- 这些发现突出了潜在的途径,将社会环境因素与该人口中MCI和阿尔茨海默病风险增加联系起来.
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