在三级新生儿重症监护室中新生儿角膜炎的概况:来自发展中国家的报告
1Department of Neonatology, Institute of Post-Graduate Medical Education & Research and SSKM Hospital, Kolkata, India.
Journal of neonatal-perinatal medicine
|September 18, 2023
概括
新生儿角膜炎越来越多地出现在早产的婴儿身上,其中非白类的Candida物种占主导地位. 这些感染对常见的抗真菌药物表现出耐药性,影响新生儿重症监护病房的死亡率.
科学领域:
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
背景情况:
- 系统性角膜炎是新生儿重症监护病房 (NICU) 中的一种重大医院感染.
- 了解新生儿角膜炎的不断变化的特征对于有效的管理至关重要.
研究的目的:
- 在印度东部的第三级NICU中识别新生儿角膜炎的形状变化.
- 分析与新生儿角膜炎相关的人口因素,风险因素和结果.
主要方法:
- 对2014年至2019年的病例记录进行了回顾性审查.
- 分析了103名患有真菌性败血症的新生儿的数据,包括人口统计,风险因素和死亡率.
主要成果:
- 非白类的Candida (NAC) 种类占主导地位 (79.6%),在早产婴儿中出现明显的白病发病率.
- 风险因素包括长时间使用抗生素和美罗,中央导管和机械通风.
- 在18.4%的病例中观察到抗抗药性于可纳和安福特里辛B.
结论:
- 新生儿角膜炎主要影响出生的婴儿,出生体重和妊娠年龄较高.
- NAC物种是主要的致病原体,对常见的抗真菌药物表现出耐药性.
- NAC感染和双抗真菌耐药性是NICU环境中死亡率的独立预测因素.
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