中年和老年男性的CAG重复数量和死亡率
Adrian Heald1,2, Michael J Cook3,4, Leen Antonio5,6
1Department of Endocrinology and Diabetes, Salford Royal Hospital, Salford, UK.
Clinical endocrinology
|September 18, 2023
概括
雄激素受体 (AR) CAG重复数与男性的死亡率没有关联. 然而,较低的丸激素水平可能与AR CAG重复相互作用,这表明与死亡率的潜在联系需要进一步研究.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
- 老年学是一门学科.
背景情况:
- 雄激素受体 (AR) 在调解的外围作用方面发挥着关键作用.
- 之前的研究表明,AR基因的外形-1和AR转录活性中的CAG重复数量之间存在相关性.
研究的目的:
- 调查AR CAG重复数量与男性全因死亡率之间的关联.
- 为了确定丸激素水平是否会影响这种关联.
主要方法:
- 利用了欧洲男性衰老研究 (2003-2005) 对40-79岁男性的随访数据.
- 采用Cox比例危险建模来分析AR CAG重复数和死亡率之间的关系.
- 进行多变量和后期分析,考虑基线水平.
主要成果:
- 总的来说,在欧洲队列中,AR CAG重复数和全因死亡率之间没有发现显著的关联.
- 一个多变量模型显示,与22-23次重复相比,在<22或>23次AR CAG重复的男性中,死亡率没有显著的危险比率.
- 后期分析显示,男性基线水平较低 (<14.2 nmol/L) 和AR CAG重复次数>23 (HR: 1.68,95% CI: 1.06-2.67) 的男性存在潜在关联.
结论:
- 在欧洲队列中,AR CAG重复的数量与男性全因死亡率没有显著的关联.
- 较低的基线丸激素度可能会改变AR CAG重复和死亡率之间的关系,这表明需要进一步研究.
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