德诺苏马布对老年患者对骨密度和骨折风险的影响
Sung-Hyun Yoon1, Karam Kim1, Ki-Choul Kim1
1Department of Orthopaedic Surgery, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea.
Journal of bone metabolism
|September 18, 2023
概括
德诺苏马布有效增加骨矿物质密度 (BMD),并降低80岁以上老年患者骨折风险. 这种骨质疏松症治疗在这个脆弱人群中对骨健康有显著的长期益处.
科学领域:
- 老年学是一门学科.
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于人口老龄化,骨质疏松症的诊断和治疗变得越来越重要.
- 骨质疏松症被视为老年变化,而不仅仅是内分泌.
- 德诺苏马布是一种流行的骨质疏松症药物,以增加骨矿物质密度 (BMD) 和其方便的6个月剂量周期而闻名.
研究的目的:
- 为了研究denosumab的骨矿物质密度 (BMD) 增加效果.
- 评估德诺苏马布在降低80岁以上个体骨折风险方面的疗效.
- 为了证实先前关于登索马布对老年人骨健康的影响的发现.
主要方法:
- 从2018年至2022年接受德诺苏马布治疗的患者的回顾性评估.
- 最少12个月的临床观察期,每12个月测量一次骨质量.
- 使用FRAX进行骨折风险评估,并在随访期间评估骨折发生率.
主要成果:
- 在腰椎,大腿部和整个部观察到BMD显著增加 (p<0.001,p<0.001,p=0.001).
- 基于德诺苏马布治疗持续时间,所有患者子组的 BMD 增加都是一致的.
- 骨折风险评估 (FRAX) 评分在12个月和≥36个月的随访组显著下降 (p=0.003,p=0.001),但在24个月 (p=0.41) 没有显著下降.
结论:
- 在80岁及以上的患者中,德诺苏马布治疗导致骨矿物质密度 (BMD) 持续增加.
- 德诺苏马布有效降低骨质疏松症的老年人骨折风险.
- 这项研究支持denosumab作为老年人骨质疏松症的长期治疗选择.
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