被动吸烟和妊娠期糖尿病风险:一个系统的审查和元分析
Haijie Zhang1,2,3, Xin Zhou4, Lixia Tian1,5
1Shanxi Health Commission Key Laboratory of Nervous System Disease Prevention and Treatment, Sinopharm Tongmei General Hospital, Datong, China.
Tobacco induced diseases
|September 18, 2023
概括
被动吸烟显著增加了妊娠期糖尿病 (GDM) 的风险. 这一元分析证实,即使是接触过二手烟的非吸烟者也面临更高的GDM发病率.
科学领域:
- 产科和妇科 产科和妇科
- 公共卫生 公共卫生
- 环境健康 环境健康
背景情况:
- 怀孕期间吸烟是已知的妊娠糖尿病 (GDM) 的风险因素.
- 全球GDM发病率正在增加,特别是在中国.
- 这一元分析的重点是被动吸烟与GDM风险的关联.
研究的目的:
- 进行一项元分析,评估被动吸烟作为GDM的风险因素.
- 量化二手烟暴露与GDM发展之间的关联.
主要方法:
- 在多个数据库 (PubMed,CNKI等) 的系统文献搜索. 在2023年5月之前.
- 使用纽卡斯尔-太华尺度 (NOS) 进行独立的数据提取和质量评估.
- 采用随机效应模型的元分析与异质性评估和出版偏差测试 (贝格,埃格).
主要成果:
- 由于被动吸烟导致的GDM显著的整体相对风险为1.47 (95% CI: 1.31-1.64).
- 在不同研究中观察到适度的异质性 (I2=41.7%,p=0.079).
- 亚组分析,敏感性分析和出版偏差测试显示了稳定可靠的结果.
结论:
- 被动吸烟被证实是妊娠期糖尿病的重要危险因素.
- 建议进行进一步的大规模前性队列研究,以阐明混因素的关系和控制.
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