胃癌前病变:发生情况,发展因素和治疗方法
Yue Cao1, Dongcai Wang1, Guiyun Mo2
1Emergency of Department, Yunnan Provincial Hospital of Traditional Chinese Medicine, The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China.
Frontiers in oncology
|September 18, 2023
概括
胃癌前病变 (GPL) 会增加胃癌的风险. 将传统中医与西方疗法的结合提供了有效的GPL治疗,并可能减少癌症的发展.
科学领域:
- 胃肠道学和瘤学
- 综合医学是一个整体医学.
- 分子生物学分子生物学
背景情况:
- 胃癌前病变 (GPL) 显著增加患胃癌 (GC) 的风险.
- 从GPL到GC的进展是一个多年的过程,受各种因素的影响.
- 对GLP的及时干预对于减轻GC风险至关重要.
研究的目的:
- 审查GLP的原因和进展.
- 讨论目前GLP的治疗策略.
- 探索结合中国传统医学 (TCM) 和西方治疗方法对GPL的疗效.
主要方法:
- 文献综述侧重于GLP的病因因素.
- 对GLP当前临床治疗方法的分析,包括内镜和药理学方法.
- 检查关于TCM和集成TCM-西方医学用于GLP和H. pylori根除的研究.
主要成果:
- 在GPL转化为GC中确定了关键因素:H. pylori,植物不平衡,炎症,遗传变异,Claudin-4,胃干细胞,SLC26A9,胆汁反流,外体和miR-30a.
- 标准治疗包括内镜,酸抑制,H. pylori根除,NSAIDs和饮食改变.
- 传统医学,特别是与西方医学相结合,在治疗亚洲人群中的GPL和根除H. pylori方面显示出显著的临床疗效.
结论:
- 了解GPL的多因素病因是有效管理的关键.
- 结合TCM和西方医学的综合方法是治疗GPL的有希望的策略.
- 对综合疗法的进一步研究可能会增强胃癌的预防和治疗.
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