感染艾滋病毒/艾滋病的非洲儿童的左心室缩:一个病例控制研究
Ijeoma Ogugua Arodiwe1, Christopher Bismarck Eke1, Ejikeme Benneth Arodiwe2
1Department of Paediatrics, College of Medicine, University of Nigeria Enugu Campus, Enugu, Nigeria.
The Pan African medical journal
|September 18, 2023
概括
左心室缩 (LVH) 在患有人类免疫缺陷病毒/获得性免疫缺陷疾病 (HIV/AIDS) 的儿童中很普遍. 下肢体质量指数 (BMI) 和CD4+细胞计数是这一群体中LVH的关键预测指标.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 左心室缩 (LVH) 是人类免疫缺陷病毒/获得免疫缺陷疾病 (HIV/AIDS) 患者的一个重大问题,有助于增加发病率和死亡率.
- 艾滋病毒/艾滋病的血液动力学和代谢变化可能导致不良的心脏重塑,特别是LVH.
研究的目的:
- 确定艾滋病毒/艾滋病诊断的非洲儿童中LVH的患病率.
- 在这个儿科群体中确定与LVH相关的风险因素.
主要方法:
- 一项分析性病例对照研究,利用心声学来评估心脏功能.
- 用描述性统计和单变量分析来确定关联,然后用多变量建模来确认预测器的强度.
主要成果:
- 在67.7%的艾滋病毒/艾滋病儿童中观察到LVH.
- 根据年龄,较低的体重指数 (BMI) 和较低的CD4+细胞计数被确定为LVH的显著预测因素.
- 与对照组相比,平均左心室质量指数和相对壁厚在病例中显著更高.
结论:
- LVH 的高患病率强调了需要对艾滋病毒/艾滋病儿童进行心血管监测.
- 较低的BMI和CD4+细胞计数是儿童艾滋病毒/艾滋病LVH风险的关键指标.
- 在治疗儿科艾滋病毒/艾滋病方面支持基线和周期性心声回声学的建议.
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