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Updated: Jul 16, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

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单个GWAS风险位中的多个基因协同调解了人类神经元中的异常突触发育和功能

Siwei Zhang1,2, Hanwen Zhang1, Marc P Forrest3,4

  • 1Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA.

Cell genomics
|September 18, 2023
PubMed
概括

精神分裂症风险变异影响基因表达和神经元功能. 这项研究将遗传风险因素与细胞变化联系起来,揭示了神经精神疾病中的协同基因效应.

关键词:
基因编辑CRISPR-Cas9基因编辑在CROP-seqq.在GWAS中,GWAS就是GWAS.微-C 微-C 是一个微-C.特定于基因基因的开放色素.染色质可访问性 染色质可访问性常见的风险变体常见的风险变体人类的iPS细胞.是同源性的同源性.神经元神经元是一个神经元.神经精神疾病:神经精神疾病.没有编码的变体.这就是 scRNA-seqq.精神分裂症是一种精神分裂症.有协同作用的协同作用.

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