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Updated: Aug 14, 2026

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一个单细胞的景观的三类体相关的丸毒性在小鼠

Wei Zhang1, Siyu Xia1, Jinhuan Ou1

  • 1Department of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, China.

Journal of pharmaceutical analysis
|September 18, 2023
PubMed
概括

特里普托利德通过增加炎症和氧化应激导致丸毒性. 这项研究揭示了它对不同丸细胞类型的单细胞分辨率的影响,确定了男性生殖毒性的潜在治疗标.

关键词:
生殖毒性 有毒性 生殖毒性一个单细胞序列的序列.测试 (Testis) 是一个测试.文字转录学 (Transcriptomics) 是一个学科.三托利化物是什么

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...