在患有慢性疾病的患者中,COVID-19的临床结果
Yasar Sertbas1, Ebru Elci Solak2, Selma Dagci3
1Department of Internal Medicine, Health Sciences University, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye.
患有慢性疾病 (CD) 的COVID-19患者面临更高的重症监护室 (ICU) 入院和死亡风险. 诸如高血压,糖尿病和癌症等特定疾病独立增加了ICU风险,而心血管疾病,慢性病和精神疾病则增加了死亡风险.
科学领域:
- 医学研究 医学研究
- 传染病 传染病 传染病
- 公共卫生 公共卫生
背景情况:
- COVID-19显著影响全球健康,慢性疾病 (CD) 是一个主要问题.
- 了解COVID-19和先前存在的疾病之间的相互作用对于患者管理至关重要.
研究的目的:
- 评估感染COVID-19的慢性疾病 (CD) 患者的临床结果.
- 确定特定的慢性疾病,增加COVID-19患者严重后果的风险.
主要方法:
- 追溯性研究包括1,516名被诊断为COVID-19和先前存在的慢性疾病的患者.
- 评估的慢性疾病包括心血管疾病,糖尿病 (DM),高脂血症,喘,慢性阻塞性肺部疾病,类风湿病,恶性瘤,脑血管疾病和慢性脏疾病 (CKD).
- 进行了统计分析,以确定住院,重症监护室 (ICU) 入院和死亡率的风险因素.
主要成果:
- 68.9%的COVID-19患者患有至少一种慢性疾病;女性患病率比男性 (64.8%) 高 (73.8%).
- 患有CD的患者年龄大得多,住院时间较长,需要ICU入院的可能性增加5.49倍,死亡率提高2.52倍.
- 接受ICU治疗的独立风险因素包括高血压 (HT) (OR:2.39),DM (OR:3.64) 和癌症 (OR:2.75).
- 死亡的独立风险因素包括心血管疾病 (OR: 2.27),CKD (OR: 3.69) 和精神疾病 (OR: 2.18).
结论:
- 患有慢性疾病的COVID-19患者需要更谨慎的临床随访.
- 患有HT,DM和癌症的患者有更高的ICU入院风险.
- 患有脑血管疾病,CKD和精神疾病的患者面临死亡风险增加.
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