福科西尔转移酶3基因的多态性与炎症性肠病有关:系统性审查
相关实验视频
Updated: Jul 16, 2025
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.2K
1Department of Public Health, School of Basic Medical Science, Putian University, Putian, Fujian 351100, China.
Asian biomedicine : research, reviews and news
|September 18, 2023
概括
FUT3基因rs3745635多态可能会影响炎症性肠病 (IBD) 的风险. 其他FUT3基因变异,rs3894326和rs28362459,与IBD易感性没有显著关联.
科学领域:
- 遗传学 是一个遗传学.
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
背景情况:
- 炎症性肠病 (IBD) 涵盖了具有复杂,不太了解遗传基础的慢性胃肠道疾病.
- 福科西转移酶3 (FUT3) 基因是影响IBD易感性的潜在候选者.
研究的目的:
- 系统地评估特定的Fucosyltransferase 3 (FUT3) 基因多态化与发展炎症性肠病 (IBD) 的风险之间的关联.
主要方法:
- 通过PRISMA和PICOS指南确定的病例控制研究进行了元分析,数据收集到2020年4月30日.
- 两位独立审稿人使用纽卡斯尔-太华尺度进行了研究选择,数据提取和质量评估.
- 统计分析包括元分析,敏感性分析和埃格尔出版偏差测试.
主要成果:
- 分析包括12项病例控制研究,包括1712名IBD患者和1903名对照.
- 这种多态性显示出与IBD易感性有显著的关联 (例如,GG与AA:OR2.38,95%CI1.52-3.74).
- 对于rs3894326和rs28362459的多态与IBD风险没有发现显著的关联.
结论:
- 在FUT3基因中的多态性可能与炎症性肠病易感性有关.
- "FUT3"基因的多态性rs3894326和rs28362459似乎与IBD风险没有显著的关联.
更多相关视频
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
354
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
354
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
213
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
213
01:29Inflammatory Bowel Disease IV: Pharmacological Management
152
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
152
01:30Inflammatory Bowel Disease II: Crohn's Disease
285
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
285
01:17Chronic Bowel Disorders: Introduction
478
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
478
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
168
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
168