致命的气管食道穿孔泄漏与伦瓦替尼布相关
Sarah Salvatori1, Tawee Tanvetyanon2
1Medicine, University of South Florida Morsani College of Medicine, Tampa, USA.
Cureus
|September 18, 2023
概括
伦瓦替尼 (Lenvatinib) 是一种癌症药物,可能会导致头癌患者的气管食道穿刺 (TEP) 泄漏. 这种罕见的并发症在喉癌患者中观察到,可能是致命的,强调了临床意识的必要性.
科学领域:
- 在瘤学瘤学.
- 手术并发症 手术并发症
背景情况:
- 气管食道穿刺 (TEP) 是一种常见的声音恢复方法,用于喉切除患者.
- 铁氨酸激酶抑制剂 (TKIs),像伦瓦替尼,用于头癌,但携带器官穿孔的风险.
- 关于伦瓦替尼与TEP泄漏的相关文献很少.
研究的目的:
- 报告首例已知与伦瓦提尼布治疗相关的致命气管食管穿孔泄漏病例.
- 提高临床医生对TEP患者这种潜在的TKI相关并发症的认识.
主要方法:
- 病例报告描述了一个患有喉腺囊性癌症和TEP的患者.
- 伦瓦提尼布治疗开始后不久发生的TEP泄漏的文档.
- 对临床过程,干预措施和结果的审查,包括死亡原因.
主要成果:
- 一名患者在开始服用伦瓦替尼布后大约两周就出现了TEP泄漏.
- 尽管进行了多次干预,但泄漏仍然存在.
- 这位患者最终死于Fusobacterium nucleatum引起的腹.
结论:
- 伦瓦替尼布治疗可能与快速发作和潜在致命的TEP泄漏有关.
- 临床医生必须考虑这一风险,在给有TEP病史的患者开处方TCI时.
- 需要进一步研究与伦瓦提尼布相关的TEP并发症的机制和发病率.
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