血小板参数对在住院患者中与林氏素相关的血小板缺血的影响
1Department of Pharmacy, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Infection and drug resistance
|September 18, 2023
概括
在住院患者中,莱涅佐利德治疗可能会导致血小板减少,即血小板数量较低. 关键的风险因素包括平均血小板体积和血小板大细胞比率的变化,以及基线血小板计数和治疗持续时间.
科学领域:
- 药理学 药理学是指药理学的学科.
- 血液学 血液学 血液学
- 临床医学 临床医学
背景情况:
- 利尼佐利德是一种抗生素,诱导血小板缩的发病率可变.
- 很少有研究研究了与线索利德相关的血小板减少的风险因素,除了血小板计数之外.
- 血小板参数,如平均血小板体积和血小板大细胞比率,需要进一步研究.
研究的目的:
- 分析血小板参数对与线索利德相关的血小板缺血的影响.
- 为了确定与linezolid诱导的血小板缺血相关的危险因素.
- 为了比较在线索利德治疗期间患有和没有血栓塞缩症的患者之间的死亡率.
主要方法:
- 用单变量和多变量逻辑回归来确定血小板参数效应.
- 卡普兰-梅尔生存分析基于血小板缺血发育的患者生存率进行了比较.
- 分析了接受linezolid的住院患者的数据.
主要成果:
- 在接受linezolid治疗的住院患者中,41.5%发生了血小板缩.
- 与血小板缺血的显著关联包括平均血小板体积 (MPV) 和血小板大细胞比率 (PLCR) 的差异,基线血小板计数和线索的持续时间 (≥10天).
- 与没有 (8.6%) 患者相比,患有血小板缺血的患者 (19.7%) 的住院死亡率更高.
结论:
- 血小板平均体积和血小板大细胞比率的变化是与线索利德相关的血小板缺血的重要因素.
- 基线血小板计数和长期的线索利德治疗 (≥10天) 也有助于血小板缺血风险.
- 利尼佐利德诱导的血小板缺血与增加的住院死亡率有关.
相关概念视频
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
559
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
559
01:18Structure and Function of Platelets
1.2K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.2K
01:22Formation of the Platelet Plug
6.6K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.6K
01:29Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
01:30Venous Thrombosis IV: Nursing Management
14
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
14