相关实验视频

Updated: Jul 16, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

从单细胞奥米克数据和域知识推断基因网络,用于构建特定于COVID-19的ICAM1相关途径

Mitsuhiro Odaka^1,2,3,4, Morgan Magnin^2,3, Katsumi Inoue^1,2,3

¹The Graduate University for Advanced Studies, SOKENDAI, Tokyo, Japan.

Frontiers in genetics

|September 18, 2023

概括

这项研究确定了涉及SARS-CoV-2细胞间传播和COVID-19严重程度的新型细胞间粘附分子1 (ICAM-1) 信号通路. 发现这些ICAM-1通道可以提高对COVID-19机制的理解.

科学领域:

分子生物学分子生物学
病毒学病毒学
免疫学免疫学免疫学

背景情况:

细胞间粘附分子1 (ICAM-1) 对于细胞相互作用至关重要,并与病毒传播有关 (HIV-1,HTLV-1).
SARS-CoV-2 与这些病毒具有共同的特征,其细胞间传播与COVID-19的严重程度相关.
在COVID-19患者中ICAM-1表达的变化,但其相关的信号通路在这种情况下仍然未被确定.

研究的目的:

为了确定COVID-19中未知的ICAM-1-关联信号通路.
阐明SARS-CoV-2细胞间传播的机制及其与COVID-19严重程度的联系.
为完成COVID-19疾病地图做出贡献.

主要方法:

基因网络推断使用单细胞奥米克数据.
对共同表达的基因进行分析,去除虚假的相关性.
使用多个知识库验证推断模型.

主要成果:

通过整合数据驱动和基于知识的方法构建ICAM-1相关途径.
确定了两个新的途径:一个涉及非正规NF-κB途径的上游途径和一个涉及整体蛋白和细胞骨蛋白的下游途径.
已知途径在不同细胞类型和时间点的可复制性.

结论:

该研究成功地确定了与COVID-19相关的新型ICAM-1-关联途径.
这些发现提供了对SARS-CoV-2传播和疾病机制的见解.
结果有助于完善COVID-19疾病地图,以更好地理解和潜在的治疗策略.

关键词:

在 COVID-19 疫情中,在 ICAM-1 中.从细胞到细胞的传输.数据驱动和基于知识的方法.模型验证模型验证路径丰富分析的分析方法一个单细胞的OMIC数据分析数据分析.

更多相关视频

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

相关概念视频

Overview of Cell-Matrix Interactions

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...