针对功能性便秘患者的肠道微生物群和短链脂肪酸的影响:一项随机的安慰剂对照试验
Xiang-Yun Yan1, Jun-Peng Yao1, Yan-Qiu Li1
1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
针通过重塑肠道微生物群和增加酸,有效治疗功能性便秘 (FC). 特定的微生物,如乳酸菌和Coprobacter预测治疗的成功.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 综合医学是一个整体的医学.
背景情况:
- 功能性便秘 (FC) 显著影响生活质量.
- 肠道微生物群失生症与FC病变发生有关.
- 针是一种潜在的治疗选择FC.
研究的目的:
- 评估针对FC患者肠道微生物群的影响.
- 为了识别与针疗效相关的微生物和代谢物.
- 探索短链脂肪酸 (SCFA) 在针治疗中的作用.
主要方法:
- 一个随机的,安慰剂对照试验,涉及80名FC患者和28名健康对照.
- 针或假针治疗超过4周.
- 16S rRNA基因测序用于肠道微生物群分析,GC-MS用于SCFA量化.
主要成果:
- 与假相比,针改善了临床症状,包括完全自发性肠道排便 (CSBM) 和生活质量.
- 针调节了肠道微生物群的组成,增加了有益的细菌 (例如,乳酸菌) 和减少了致病性细菌 (例如,伪omonas).
- 观察到酸水平增加,与改善肠道排便和减少病原体相关. 特定的微生物预测了高准确度的临床疗效 (AUC = 0.918).
结论:
- 针是通过肠道微生物群调节和增加丁酸盐生产来有效改善FC症状的.
- 包括Lactobacillus和Coprobacter在内的关键微生物属是预测针疗效的潜在生物标志物.
- 需要进一步的研究来证实因果关系,并制定个性化的针策略.
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