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Updated: Jul 16, 2025

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对比MDGA1和MDGA2的突触作用

Michael A Bemben1, Matthew Sandoval2,3, Aliza A Le2,3

  • 1Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94158, USA.

bioRxiv : the preprint server for biology
|September 18, 2023
PubMed
概括

含有甘氨基酸酸氨基1和2 (MDGA1和MDGA2) 蛋白质的MAM域在大脑突触中发挥着不同的作用. MDGA1影响刺激性传播,而MDGA2调节抑制性传播,并作为突触抑制剂.

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Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
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