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聚炎中颗粒瘤的活性及其与中性粒细胞中mTOR脂蛋白组的相关性

Marcin Surmiak¹, Katarzyna Wawrzycka-Adamczyk², Joanna Kosałka-Węgiel²

¹Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland.

Frontiers in immunology

|September 18, 2023

概括

在带有多炎 (GPA) 的颗粒瘤症中,受抑制的哺乳动物目标拉巴胺素 (mTOR) 信号传输与中性粒细胞外细胞陷形成 (NETosis) 有关. 这一发现表明,自可能在GPA颗粒瘤的发展中起作用.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
类风湿病学类风湿病学

背景情况:

带有多管炎 (GPA) 的颗粒性血管炎是一种小血管血管炎,其特征是复杂的病理机制和器官损伤.
中性细胞外细胞陷形成 (NETosis) 参与了GPA的发病.

研究的目的:

为了研究在哺乳动物的目标拉巴胺素 (mTOR) 途径中光蛋白的功能状态,该途径调节了GPA中的NETosis.
分析与这些脂蛋白相关的NETosis生物标志物.

主要方法:

从42名GPA患者 (21名活跃,21名缓解) 和21名健康对照中分离出了中性粒细胞.
测量和比较了脂蛋白水平和血清生物标志物GPA活性.
主要成分分析被用来对疾病状态进行分类.

主要成果:

活跃的GPA中性粒细胞显示酸化mTOR,PTEN和ULK1的减少,酸化GSK-3α/β的增加.
网症的生物标志物,包括dDNA和线粒体DNA,在活跃的GPA中升高.
发现了蛋白水平和GPA活性生物标志物之间的相关性,使用PCA.使用高分类性能 (98%).

结论:

抑制的mTOR信号与GPA患者的NETosis有关.
蛋白质的形状表明NETosis和自的同时激活.
对自在GPA颗粒瘤形成中的作用进行进一步研究是有必要的.

关键词:

自自是自的过程.带有多阳性炎的颗粒瘤症.拉帕米的哺乳动物标是拉帕米.线粒体DNA是线粒体DNA的组成部分.中性粒细胞外细胞陷中性粒细胞中性粒细胞.

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