在安大略省使用行政数据库治疗胆道癌症患者的现实治疗模式和生存结果
Soo Jin Seung1, Hasnain Saherawala1, Iqra Syed2
1HOPE Research Centre, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Journal of gastrointestinal oncology
|September 18, 2023
概括
在安大略省,胆道癌症患者最常接受西斯普拉丁和凝胺一线治疗. 接受治疗的患者的生存率有所改善,这凸显了对更有效的全身疗法的未满足需求.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 癌症研究 癌症研究
背景情况:
- 关于加拿大胆道癌 (BTC) 的治疗模式和治疗结果的数据有限.
- 了解这些模式对于改善加拿大安大略省患者护理和治疗结果至关重要.
研究的目的:
- 调查加拿大安大略省BTC患者的治疗模式,生存结果和医疗资源利用情况.
- 确定当前的治疗方法及其对各种BTC亚型的生存的影响.
主要方法:
- 用加拿大安大略省的行政数据进行人口层面的回顾性研究.
- 纳入标准:在2010年1月1日至2019年12月31日期间被诊断患有晚期或转移性BTC的患者.
- 对接受的治疗,生存数据和患者人口统计数据的分析.
主要成果:
- 总共有2,142名BTC患者被确定,肝内胆管癌是最常见的亚型 (32.8%).
- 西斯普拉丁加上凝丁是主要的第一线治疗 (75.2%),其次是FOLFOX/FOLFIRI (11.5%).
- 接受全身治疗的患者与未接受治疗的患者 (中位数为3.3个月) 相比,总生存期显著更高 (中位数为14.1个月).
结论:
- 金和宝石的组合是安大略省BTC的标准一线治疗方法.
- 很少有患者接受二线治疗,这表明需要改善治疗顺序.
- 这项研究强调了对更有效的全身疗法的重大未满足需求,以改善高级BTC的存活率.
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