胃腺癌的当前管理:一个叙事性回顾
Yehonatan Nevo1, Lorenzo Ferri1
1Division of Thoracic and Upper Gastrointestinal Surgery, Montreal General Hospital, McGill University, Montreal, Quebec, Canada.
Journal of gastrointestinal oncology
|September 18, 2023
概括
胃腺癌的管理因阶段而异,从早期病例的内镜切除到手术和晚期疾病的向治疗. 免疫疗法对转移和外科手术期间的情况有前途,特别是在PD-L1阳性患者中.
科学领域:
- 胃肠道学和瘤学
- 手术瘤学手术瘤学
- 医学瘤学 医学瘤学
背景情况:
- 胃腺癌是全球癌症死亡的重要原因之一.
- 治疗策略高度依赖于瘤的阶段和特征.
- 针对性疗法和免疫疗法的进步正在改变治疗模式.
研究的目的:
- 审查不同阶段的胃腺癌的当前管理策略.
- 突出外科手术,术后疗法和向药物的作用.
- 讨论免疫疗法和生物标志物导向疗法的新兴作用.
主要方法:
- 关于胃腺癌管理的当前文献的综述.
- 基于瘤阶段和分子特征的治疗结果分析.
- 对向疗法 (VEGF,VEGFR-2,HER2) 和免疫疗法 (检查点抑制剂) 的评估.
主要成果:
- 早期的胃癌是通过内镜切除的管理,如果边缘是明确的.
- 局部发达的疾病需要最佳的手术切除,通常是经外科手术或辅助疗法.
- 通过检查点抑制剂和生物标志物导向治疗,转移性疾病的存活率得到改善,在外科外科设置中正在进行研究.
结论:
- 胃腺癌的治疗取决于阶段,包括内镜切除,手术和全身疗法.
- 向疗法 (例如HER2) 和免疫疗法 (例如PD-L1抑制剂) 提供了新的途径,特别是在晚期和转移性疾病中.
- 需要进一步的研究来优化外科手术期间的免疫疗法,并了解其在微观卫星不稳定性高的瘤中的作用.
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