聚合物终端组在核内对帕克利塔塞尔加载促进和突发释放抑制的作用
Haiwei He1, Nian Huang2, Zhiwen Qiu3
1Department of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai, China.
Journal of gastrointestinal oncology
|September 18, 2023
概括
在聚合物基上定制终端组显著影响癌症治疗中帕克利塔塞尔 (PTX) 输送. 一个疏水的Phen末组增强PTX加载和减缓释放,提高治疗潜力.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 帕克利塔塞尔 (PTX) 对晚期食道和胃癌至关重要.
- 聚合物微粒增强PTX药物加载效率.
- 两胞性块上的末端组对微细胞药物加载和释放动力学产生了关键影响.
研究的目的:
- 调查终端组定制对聚合物微粒性质的影响.
- 合成和表征具有明显的疏水性末端组的块共聚物.
- 评估终端组修改对帕克利塔塞尔加载和释放的影响.
主要方法:
- 通过另一种单体添加方法,合成具有不同的末端组 (HOOC-PBMA-PNAM-Phen和HOOC-PNAM-PBMA-Phen) 的多聚-n-丁甲酸盐-块-多聚-N-烯酸) 共聚物.
- 使用质子核磁共振光谱学和差分扫描热度计的表征.
- 使用传输电子显微镜和动态光散射进行形态学和粒子大小分析.
主要成果:
- 两个块共聚合物,HOOC-PBMA-PNAM-Phen和HOOC-PNAM-PBMA-Phen,已经成功合成.
- 微粒呈现出不同的粒子大小 (分别为40nm和235nm).
- 与HOOC-PBMA-PNAM-Phen.Phen相比,HOOC-PNAM-PBMA-Phen小粒显示出明显更高的PTX加载效率和更慢的PTX释放速度.
结论:
- 在核心形成块上的疏水性Phen终端组增强了帕克利塔塞尔负载.
- 末组的存在抑制了突发释放,延长了药物递送时间.
- 定制终端组为优化基于聚合物菌根的药物递送系统提供了一种策略.
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