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认知行为疗法对化疗诱导的副作用和免疫功能的影响,在接受化疗的结直肠癌患者中:随机对照试验的研究协议
Meijuan Wang1, Yuanhong Xu1, Jingqing Shi1
1Department of Psychiatry, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai, China.
Journal of gastrointestinal oncology
|September 18, 2023
概括
认知行为疗法 (CBT) 可以减少化疗副作用,并改善结直肠癌 (CRC) 患者的免疫功能. 这项随机对照试验将调查CBT.
科学领域:
- 在瘤学瘤学.
- 心理学 心理学 心理学
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 是一种普遍的诊断,与严重的心理困扰有关,包括抑郁和焦虑.
- 认知行为疗法 (CBT) 对乳腺癌患者有明显的益处,但其对接受化疗的CRC患者的疗效尚未得到充分证实.
- CBT对化学疗法诱导的副作用和CRC患者的免疫功能的影响需要进一步研究.
研究的目的:
- 确定认知行为疗法 (CBT) 是否可以减少结直肠癌 (CRC) 患者的化疗诱导的副作用.
- 评估CBT对接受化疗的CRC患者免疫功能的影响.
- 评估CBT对CRC患者心理状态和生活质量的更广泛影响.
主要方法:
- 一个单中心随机对照试验 (RCT),将基于组的CBT (八次) 与接受化疗的CRC患者的通常护理进行比较.
- 参与者将在基线,干预后立即,干预后3个月和6个月进行评估.
- 主要结局:化疗引起的副作用. 二次结果:免疫功能 (细胞因子水平),瘤标志物,心理状态和实验室检查.
主要成果:
- 本部分应在研究完成并获得结果后填写.
结论:
- 本研究旨在提供关于CBT在管理化疗副作用和改善CRC患者免疫功能方面的实用性的临床证据.
- 这些发现将为CBT作为临床瘤学环境中的支持性护理干预措施的潜在泛化提供信息.
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