肥胖症中的外周和中央巨细胞
Sayani Mukherjee1,2,3,4, Silje Skrede5,6, Martha Haugstøyl1,2
1Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
Frontiers in endocrinology
|September 18, 2023
概括
肥胖导致慢性炎症,激活脂肪组织和大脑中的巨细胞. 这种免疫细胞激活有助于代谢疾病,如2型糖尿病和食欲失调.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢性疾病研究研究.
- 神经炎症是一种神经炎症.
背景情况:
- 肥胖与慢性,低度炎症有关.
- 脂肪组织的扩张触发了细胞应激和免疫细胞透.
- 亲炎性激活发生在对能量代谢至关重要的器官中,有助于共同疾病.
研究的目的:
- 审查外周和中央巨细胞在代谢疾病中的作用.
- 探索巨细胞如何与其他免疫细胞相互作用,促进肥胖症的炎症.
- 要突出巨细胞和微质细胞在肥胖引起的神经炎症和食欲调节中的参与.
主要方法:
- 文献综述专注于肥胖症中的巨细胞激活.
- 对脂肪组织和中枢神经系统 (CNS) 中免疫细胞相互作用的分析.
- 检查神经炎症和代谢障碍之间的联系.
主要成果:
- 脂肪组织巨细胞 (ATM) 是肥胖病原体的关键参与者.
- 肥胖引起的炎症扩展到肝脏,肌肉,胰腺和中枢神经系统.
- 微质细胞,大脑的居住性巨细胞,在肥胖中被激活,并影响养电路.
结论:
- 巨细胞,外围和中央,在与肥胖相关的代谢疾病中起着重要作用.
- 了解巨细胞和小质细胞的激活对于解决与肥胖相关的并发症至关重要.
- 准免疫细胞炎症可能为代谢障碍提供治疗策略.
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