注意缺陷/多动障碍与心血管疾病风险增加有关:系统性审查和元分析
Lin Li1,2, Honghui Yao2, Le Zhang2
1School of Medical Sciences Örebro University Örebro Sweden.
注意缺陷/多动障碍 (ADHD) 显著增加了心血管疾病 (CVD) 的风险. 这一系统性审查和元分析证实了强烈的关联,强调了进一步研究潜在机制和药物效应的必要性.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 注意缺陷/多动障碍 (ADHD) 经常与其他健康状况同时发生.
- 关于ADHD和心血管疾病 (CVD) 之间的关联现有的证据是不一致的.
研究的目的:
- 系统地审查和定量合成关于ADHD和心血管疾病之间的联系的证据.
- 评估ADHD患者心血管疾病的风险.
主要方法:
- 搜索了PubMed,Embase,PsycINFO和Web of Science数据库,从创立开始到2022年5月.
- 进行了系统审查和随机效应模型元分析.
- 使用纽卡斯尔-太华尺度评估研究质量.
主要成果:
- 包括11项研究,涉及超过1800万个人进行系统审查.
- 对调整后估计的元分析 (5项研究,超过800万个人) 显示,多动症与心血管疾病风险增加显著相关 (OR=1.96,95% CI=1.19-2.23).
- 当仅分析成年人时,异质性显著下降,这表明年龄是一个因素.
结论:
- ADHD与心血管疾病的风险显著增加有关.
- 需要进一步的研究来了解ADHD和心血管疾病之间的联系机制.
- ADHD药物在心血管疾病风险中的作用需要进一步调查.
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