在癌症治疗中Aptamers的最新进展
Swathi Venkatesan1, Kaushik Chanda2, Musuvathi Motilal Balamurali1
1Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai, Tamil Nadu 600027, India.
ACS omega
|September 18, 2023
概括
体或化学抗体为癌症诊断和治疗提供了先进的解决方案. 这篇综述强调了它们在向药物输送,神经解剖学和生物感知方面的应用,克服了传统抗体的局限性.
科学领域:
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
- 在瘤学瘤学.
背景情况:
- 在生物医学应用中,aptamers正在成为传统抗体的强大替代品.
- 它们的化学可变性允许与药物,纳米颗粒和核酸进行多功能功能化.
- 传统的抗体在稳定性,免疫性和制造方面面临局限性,而aptamers可以克服这些局限性.
研究的目的:
- 审查在癌症中aptamer功能化纳米材料的治疗和治疗应用.
- 讨论基于aptamer的药物递送系统的进展,包括受控和刺激响应释放.
- 探索aptamers在诊断中的潜力,例如电化学和免疫aptassensors.
主要方法:
- 关于癌症研究中aptamer技术的最新科学文献的综述.
- 对专注于用于药物输送的aptamer-nanomaterial结合物的研究进行分析.
- 讨论基于aptamer的生物传感平台的发展.
主要成果:
- 以aptamer功能化的纳米材料可以实现向的输送,可控/多步骤的药物释放,以及用于癌症治疗的刺激反应释放.
- 与核酸结合的阿胺体,如DNA纳米链和信标,在化疗和基因疗法中显示出多种药物加载的潜力.
- 电化学和信号增强的免疫适应传感器在敏感的癌症检测方面取得了进展.
结论:
- 阿普塔默技术对推进癌症诊断,治疗和治疗术具有显著的前景.
- 用纳米材料和核酸对体的功能化增强了它们在药物输送和基因治疗中的实用性.
- 需要进一步的研究,以克服现有的局限性,并充分实现aptamers在临床瘤学的潜力.
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