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相关实验视频

Updated: Jul 16, 2025

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

在肉山羊中使用安波特里辛B的最佳的诱导模型开发.

Mikaela M Weeder¹, Michael D Kleinhenz¹, Emily J Reppert¹

¹Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave., Manhattan KS 66502, USA.

Translational animal science

|September 18, 2023

概括

研究人员确定了AMPHOTERICIN B (amp B) 诱导山羊的最佳剂量,为疼痛研究建立了一个可靠的模型. 还开发了一种山羊微笑表 (GGS) 来评估这些动物的疼痛.

关键词:

这就是为什么BAMP BAMP B.一只山羊,一只山羊.微笑尺度的表情尺度.这就是惰,惰,惰.疼痛疼痛疼痛疼痛

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Last Updated: Jul 16, 2025

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科学领域:

兽医科学兽医科学兽医科学
动物福利动物福利
药理学药理学是指药理学的学科.

背景情况:

是山羊生产的一个重大问题,影响动物健康和福利.
氨酸B (amp B) 曾被用于诱导牲畜的短暂,用于研究.
开发可靠的症诱导模型对于研究疼痛和评估山羊干预措施至关重要.

研究的目的:

为了确定最有效的Amp B剂量来诱导肉类山羊的.
开发和验证一种面部微笑尺度 (山羊微笑尺度 - GGS) 用于评估山羊的疼痛.
为未来的山羊研究建立一个可重复的的诱导模型.

主要方法:

不同剂量的AMP B (5 mg/0.25 mL, 5 mg/0.5 mL, 2.5 mg/0.25 mL) 或盐水对照剂的关节内注射到远端间关节.
使用红外热学 (IRT),机械感知值 (MNT),视觉度评分 (VLS),视觉模拟尺度 (VAS),运动步态分析 (KGA),血皮质醇 (CORT),物质P (Sub P) 和行为评分来评估.
根据观察到的面部表情,开发了山羊微笑量表 (GGS).

主要成果:

高低 (HL) 的Amp B剂量 (5 mg/0.25 mL) 是最有效的诱导 (6/6山羊),与高高 (HH, 4/6) 和低低 (LL, 2/6) 相比.
在注射后24小时,48小时和72小时,HL组的VAS得分显著更高.
在诱导后24小时,面部微笑,表明疼痛,显著增加,支持GGS的发展.

结论:

高低剂量的安福特里辛B提供了一种有效和可重复的方法,用于诱导肉类山羊的.
开发的山羊微笑尺度 (GGS) 是一个有价值的工具,用于客观评估山羊的疼痛和痛苦.
这项研究为山羊的研究建立了一个强大的模型,有助于理解和管理这种物种的疼痛.