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通过使用硫 cationic poly ((methionine) 对抗耐药细菌

Lizhong Zhu¹, Jie Li¹, Weiwei Huan¹

¹Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, College of Chemistry and Materials Engineering, Zhejiang A&F University Hangzhou Zhejiang 311300 China.

|September 18, 2023

概括

新的合成聚合物模仿抗微生物来对抗耐药细菌. 硫聚氨酸显示广泛的活性和良好的生物相容性,为感染治疗提供了潜在的解决方案.

科学领域:

聚合物化学聚合物化学
生物材料科学生物材料科学
传染性疾病传染性疾病

背景情况:

抗生素耐药性和耐药性细菌感染是全球主要的健康挑战.
抗微生物 (AMP) 显示治疗潜力,但面临诸如高成本和蛋白酶不稳定性等局限性.
聚氨酸 (α-氨基酸) 被探索为合成AMP模仿物,以氨酸为基础的聚合物为一个显著的例子.

研究的目的:

开发一种新型的合成抗微生物 (AMP) 模仿剂.
为了研究功能性聚甲因作为阴阳性AMP模拟物的潜力.
评估这些新模仿剂对抗耐药细菌的抗菌活性,生物相容性和有效性.

主要方法:

通过聚合α-氨基酸二氧化碳化 (α-NTA) 来合成具有不同链条长度的硫酸聚 (d,l-氨酸).
使用 tert-butyl-benzylamine 的启动和随后用甲的化.
对抗生素耐药菌株的抗菌活性和与哺乳动物细胞的生物相容性的评估.

主要成果:

一系列的硫电离子聚 () 氨酸 () 已成功合成.
最佳的 metionin 聚合物表现出强大的,广泛的抗菌活性对抗耐药细菌.
该聚合物表现出与哺乳动物细胞的良好生物相容性和快速杀菌作用.

结论:

硫聚 (甲) 是一种有前途的新型合成AMP模仿剂.
这些聚合物为克服耐药细菌感染带来的挑战提供了潜在的战略.
开发的材料显示了未来治疗应用在打击抗菌素耐药性的潜力.

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