基于氧化纳米颗粒改性碳糊电极的阿里皮普拉的电化学测定
Funda Öztürk1, Elif Yüksel1, Pınar Esra Erden2
1Department of Chemistry, Faculty of Science and Arts, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
Turkish journal of chemistry
|September 18, 2023
概括
一个使用氧化纳米颗粒改性碳糊电极的新型电化学传感器增强了阿里皮拉的检测. 这种敏感的方法准确地量化了生物和制药样本中的阿里皮普拉.
科学领域:
- 电化学 电化学 电化学
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 阿里皮普拉是一种非典型的抗精神病药物,用于治疗各种心理健康状况.
- 对于治疗药物监测和质量控制而言,对阿里皮普拉的敏感和准确的检测方法至关重要.
研究的目的:
- 开发和优化一种敏感的电化学传感器,用于检测阿里皮普拉.
- 为了研究用氧化纳米颗粒修改的碳糊电极的性能,用于aripiprazole氧化.
主要方法:
- 采用了循环电压测量和方波阳极吸附剥离电压测量.
- 包括电极组成,pH值和积累条件在内的实验参数得到了优化.
- 用修改的碳糊电极进行了阿里皮普拉的检测.
主要成果:
- 修改后的电极表现出增强的灵敏度和有效表面积,用于检测阿里皮普拉.
- 阿里皮普拉在pH1.8缓冲器中在+1.17V时显示出不可逆转的阳极峰值.
- 在峰值电流和阿里皮普拉度 (0.038.0μM) 之间观察到线性关系,检测极限为0.006μM.
结论:
- 开发的电压测量方法对阿里皮普拉的确定具有高度敏感性和选择性.
- 氧化纳米颗粒修改碳糊电极为阿里皮普拉量化提供了一个有前途的平台.
- 该方法的适用性通过对人类血清和制药配方中的阿里皮普拉的分析来验证.
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