斯夸伦与β-环氧化和甲基-β-环氧化的纳入复合物:制备和表征
Anh Van Nguyen1, Victor I Deineka2, Anh Thi Ngoc Vu3
1Faculty of Food Science and Technology, Ho Chi Minh City University of Food Industry, Ho Chi Minh City, Vietnam.
Turkish journal of chemistry
|September 18, 2023
概括
这项研究探讨了与循环德克斯特林的烯纳入复合物,证实了成功的复合. 在优化条件下,产生了一种带有改善水分散性的烯-环氧烯复合物.
科学领域:
- 制药科学 制药科学
- 超分子化学 超分子化学
背景情况:
- 斯卡烯是一种天然的三烯,由于水溶性差,其生物利用性有限.
- 环极素 (CDs) 是循环寡糖类,能够形成包含复合体,以提高客分子的溶解性和稳定性.
研究的目的:
- 调查与本地β-环氧化 (β-CD) 和甲基β-环氧化 (MβCD) 的squalene纳入复合物的形成和特征.
- 为了优化 squalene-β-CD 纳入复合物的制备条件.
- 为了评估循环德克斯特林修饰对复杂性质的影响.
主要方法:
- 响应表面方法 (RSM) 用于优化复杂的准备.
- 福利埃变换红外光谱 (FTIR),X射线衍射测量 (XRD),热分析 (DSC/TGA) 和H-NMR光谱测量用于表征.
- 逆相高性能液态染色学 (RP-HPLC) 用于量化含量.
- 密度函数理论 (DFT),分子力学 (MM2) 和MøllerPlesset扰动理论 (MP2) 用于计算机模拟.
主要成果:
- 通过多种分析技术证实了与β-CD和MβCD相结合的squalene纳入复合物的成功形成.
- 经过优化制备,产生了一种烯-β-CD复合物,产量为54.3%,烯含量为9.01%.
- 与β-CD复合体不同的是,烯-MβCD复合体表现出增强的水分散性和没有沉物形成.
结论:
- 烯可以有效地被封装在循环德克斯特林腔内.
- 对于素复合,MβCD比原生β-CD具有优势,特别是在可分散性方面.
- 计算方法证实了关于包含复杂形成和几何学的实验发现.
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