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介素-6和表皮生长因子作为慢性淋巴结膜炎进展的非侵入性生物标志物

Ilona Idasiak-Piechocka¹, Miłosz Miedziaszczyk¹, Aldona Woźniak²

¹Department of Nephrology, Transplantology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

American journal of physiology. Cell physiology

|September 18, 2023

概括

尿中高素-6 (IL-6) 和尿中低皮表皮生长因子 (EGF) 水平预测慢性淋巴结膜炎的进展. 这些生物标志物在预测功能下降方面比初始的eGFR或蛋白尿更有效.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
免疫学免疫学免疫学
生物标志物发现发现

背景情况:

细胞因子和化学因子涉及慢性淋巴结膜炎 (CGN) 病原和损伤.
需要预后生物标志物来预测CGN患者的功能下降.

研究的目的:

评估尿路中介素-6 (IL-6),转化生长因子β1 (TGFβ1),单细胞化学吸引蛋白-1 (MCP-1),可溶性瘤缩因子受体1 (sTNFR1) 和表皮生长因子 (EGF) 作为新诊断的CGN的预后生物标志物.
为了确定这些尿路标志物是否预测渐进性功能丧失.

主要方法:

酶相关免疫吸收试验 (ELISA) 用于测量150名高加索CGN患者的尿IL-6,TGFβ1,MCP-1,sTNFR1和EGF.
进行了多变量和逻辑回归分析,以确定功能恶化的预测因素.

主要成果:

高尿IL-6,TGFβ1,MCP-1,sTNFR1和较低尿EGF在患有脏综合征的患者,较低的EGFR (<60毫升/分钟/1.73米2) 和进步子组中观察到.
在随访期间,尿路EGF分泌与ΔeGFR显著相关.
高基线尿IL-6和低尿EGF是功能下降的显著独立风险因素,优于初始EGFR和蛋白尿.

结论:

尿液IL-6和EGF作为有价值的预后生物标志物,用于预测新诊断的CGN患者的疾病进展.
IL-6/EGF比率是功能恶化的强有力的预测指标.

关键词:

生物标志物生物标志物慢性淋巴结膜炎 (glomerulonephritis) 是一种慢性淋巴结膜炎.这是一个渐进的过程.

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