在Mycobacterium tuberculosis中的诺基诺抗性突变及其与治疗结果的相互联系
Ramakant Dixit1, Emil Mohan1, Ankur Gupta1
1Department of Respiratory Medicine, J. L. N. Medical College, Ajmer, Rajasthan, India.
International journal of mycobacteriology
|September 18, 2023
概括
GyrA D94G突变在广泛耐药结核病中很常见,并且与治疗结果不佳有关. 这一发现有助于理解Mycobacterium tuberculosis中基诺抗性的发现.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 传染性疾病 传染性疾病
背景情况:
- 诺基诺 (FQ) 抗生素是结核病 (TB) 的关键二线治疗方法.
- 了解耐药性Mycobacterium结核病的遗传突变对于有效的治疗策略至关重要.
研究的目的:
- 分析在前广泛耐药 (XDR) 和广泛耐药 (XDR) 结核菌中发生的基因突变的频率和模式.
- 将耐药突变与治疗结果进行比较.
主要方法:
- 在患者样本 (唾液,淋巴结吸附物,冷) 上使用一线和二线线探针测定 (LPA).
- 评估了对诺基诺 (莱沃素,莫西素) 的额外药物耐药性.
- 与最终治疗结果比较突变概况.
主要成果:
- 在150名受试者中发现了与FQ耐药性相关的突变.
- 最常见的GyrA D94G突变 (Gyr A MUT3C) 是最常见的 (66%),它对勒沃素和莫西素产生了高水平的耐药性.
- 这种突变与不良结果 (死亡或治疗失败) (OR 2.50,RR 1.67,P=0.043) 相相关.
- 最常见的异种耐药性模式是GyrA基因中的野生类型加Asp94Gly (24.6%).
结论:
- GyrA D94G突变是Mycobacterium结核病GyrA基因中占主导地位的突变.
- 与治愈结果相比,这种突变显示出与治疗失败或死亡的显著关联.
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