动脉样硬化作为炎症性肠道疾病的危险因素:一个基于人口的病例控制研究
Adam S Faye1, Jordan E Axelrad1, Jiangwei Sun2
1Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU School of Medicine, New York, New York, USA.
The American journal of gastroenterology
|September 18, 2023
概括
患有动脉样硬化病史的个人患上炎症性肠病 (IBD) 的几率增加. 这种关联在老年人中尤其强烈,这表明动脉样硬化和IBD病变之间存在联系.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 的发病可能涉及动脉样硬化相关的炎症.
- 需要进行大规模研究来证实这一关联.
研究的目的:
- 研究先前与动脉样硬化相关的疾病与发展IBD的风险之间的关联.
- 为了确定这种关联是否在IBD亚型和年龄组之间存在差异.
主要方法:
- 使用瑞典登记册进行的全国病例控制研究 (2002-2021年).
- 确定了成年IBD病例,并将其与一般人口对照进行了匹配.
- 使用条件逻辑回归来计算先前动脉样硬化条件的几率比率 (OR).
主要成果:
- 预先诊断出与动脉样硬化相关的疾病与发展IBD的几率增加了30% (或1.30).
- 对于克罗恩氏病和性结肠炎,特别是在老年人 (≥40岁) 中观察到显著的关联.
- 在调整并发症和药物使用后,这种关联仍然存在,即使在IBD诊断前5年也观察到更高的几率.
结论:
- 动脉样硬化相关疾病的病史与患IBD的风险更高有关.
- 针对动脉样硬化炎症可能为高风险个体提供预防策略.
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