神经电路机制用于将学习的嗅觉价值转化为以风为导向的运动
Yoshinori Aso1, Daichi Yamada2, Daniel Bushey1
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
eLife
|September 18, 2023
概括
研究人员发现果如何使用记忆来指导行动. 特定大脑区的食欲记忆会触发明显的上风运动,由新发现的上风神经元 (UpWiNs) 介导.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 遗传学 是一个遗传学.
背景情况:
- 大脑使用记忆来指导未来行动的机制仍然不清楚.
- 在果中,嗅觉关联性学习涉及体区分分配刺激价值.
- 了解这个过程是解读记忆驱动行为的关键.
研究的目的:
- 为了研究存储在不同体区的记忆如何影响移动.
- 识别神经回路,将学习的价值体转化为特定的行动.
主要方法:
- 在 *Drosophila* 中使用了带有 split-GAL4 驱动器的光激活屏幕.
- 使用电子显微镜 (EM) 连接学来绘制神经电路图.
- 在记忆检索过程中记录了运动和神经反应的变化.
主要成果:
- 已识别的上风神经元 (UpWiNs) 后突触到体输出神经元 (MBONs),这些神经元控制逆风方向盘.
- UpWiNs集成来自食欲和厌恶记忆路径的输入.
- 阻断UpWiN会损害食欲的记忆回忆,并减少对风运动.
结论:
- 学习的价值观通过分离和收的神经网络转化为具体的行动.
- 上风神经元在将食欲记忆转化为指导运动中发挥着至关重要的作用.
- 这种神经元架构在不同物种中得到保护,这表明它具有广泛的适用性.
关键词:
D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. D. melanogaster. melanogaster. D. melanogaster. melanogaster. D. melanogaster. D. melanogaster. melanogaster. D.协同学习是一种协同学习.多巴胺是多巴胺的一种.记忆 记忆 记忆 记忆 记忆的身体是的身体.神经电路的神经电路.神经科学 神经科学嗅觉导航是一种嗅觉导航.相关概念视频
Physiology of Smell and Olfactory Pathway
8.6K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.6K
Olfaction
44.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.4K
Olfactory Receptors: Location and Structure
9.3K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.3K
Major Somatic Sensory Pathways
1.0K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.0K
Motor and Sensory Areas of the Cortex
4.0K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
4.0K
Diencephalon: Thalamus and Information Relay
1.7K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.7K


