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circROCK1 通过调节miR-96-5p/OXSR1轴来促进败血性心肌损伤

ZhiYu He¹, Lingling Xu¹, Xiaojun Zeng¹

¹Department of cardiovascular, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province, 510120, China.

Acta biochimica Polonica

|September 18, 2023

概括

循环RNARho相关激酶1 (circROCK1) 通过调节miR-96-5p/OXSR1通路,加剧了败血症引起的心肌损伤. 这一发现将circROCK1确定为败血性心肌功能障碍的潜在治疗标.

科学领域:

分子生物学分子生物学
心血管生物学心血管生物学
败血症研究败血症研究

背景情况:

败血症可能导致心肌损伤,但潜在的分子机制尚未完全理解.
循环RNARho相关激酶1 (circROCK1) 在败血症中被上调.
需要对circROCK1在败血症引起的心肌损伤中的作用进行研究.

研究的目的:

为了研究circROCK1在败血症引起的心肌损伤中的生物功能.
在这种情况下,阐明circROCK1的下游分子机制.
探索circROCK1作为一个潜在的治疗目标.

主要方法:

在败血症患者和小鼠模型中检测circROCK1和miR-96-5p表达.
在体内操纵circROCK1和miR-96-5p水平.
评估心脏功能和心肌损伤标志物的评估.
对炎症因素,NF-κB和OXSR1表达的分析.
双 luciferase 记者测定以确认分子相互作用.

主要成果:

在败血症中,circROCK1和OXSR1的调节上升,而miR-96-5p的调节下降.
circROCK1水平与败血症严重程度标志物相关.
沉默circROCK1改善了心脏功能,减少了心肌损伤和炎症.
circROCK1和OXSR1针对miR-96-5p,形成一个调节轴.

结论:

circROCK1通过调节miR-96-5p/OXSR1轴来促进败血症中的心肌损伤.
circROCK1代表了感染性心肌功能障碍的一个有前途的治疗标.

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