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开发安非他胺认证参考材料:从批量和连续流合成到认证协议

Thais G Silva¹, Rodrigo O M A de Souza², Bruno C Garrido³

¹Laboratório de Síntese Orgânica, Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, 21941-599, Rio de Janeiro, Brasil.

|September 18, 2023

概括

这项研究开发了一种快速有效的合成,用于安非他命衍生物的认证参考材料 (CRM),如MDA和MDMA. 这种新方法确保了高纯度,并支持法医化学和潜在的治疗应用.

科学领域:

法医化学法医化学
合成化学合成化学
分析化学分析化学

背景情况:

认证的参考材料 (CRM) 对于准确的法医分析和药物测试至关重要.
胺衍生物的现有合成方法可能缺乏效率或可扩展性.
在法医科学和制药研究中,对可靠的校准仪的需求越来越大.

研究的目的:

开发一种快速,高效和可扩展的合成安非他命衍生CRM.
为这些CRM建立一个全面的认证协议.
为法医和潜在的治疗应用生产高纯度的CRM.

主要方法:

两步合成MDA,MDMA,PMA和PMMA从沙夫罗尔和埃斯特拉戈尔.
在批量和连续流条件下优化合成.
开发一个认证协议,包括身份,同质性,稳定性和特征研究.

主要成果:

在48小时内 (批量) 达到38-61%的整体产量,在65分钟内 (连续流) 达到61-65%.
成功生产了MDA.HCl的高纯度CRM,其认证值为99.1±1.4g/100g.
为安非他胺衍生CRM建立了一个强大的认证协议.

结论:

开发的合成提供了一种开创性和高效的方法,用于生产胺衍生CRM.
高纯度的CRM对于法医化学,公共安全和潜在的治疗研究至关重要.
连续流合成在CRM生产的速度和产量方面具有显著的优势.

关键词:

瓦克尔 - 图氧化过程胺类药物和胺类药物.经过认证的参考材料.流动化学流动化学降解性氨基化是一种减少性氨基化.

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